Learning Objectives

At the conclusion of this program, participants should be able to:

Describe the pathophysiology of post-operative ileus (POI).
List two supportive options for treating POI and the evidence that supports
each option.
Discuss the efficacy and toxicity of three classes of medications that have been utilized for postoperative ileus.
Distinguish between the mechanisms of action of peripherally active opioid receptor antagonists from currently available drug therapies for the
treatment of POI.
List two factors that will may be considered when reviewing the mu-receptor antagonists for formulary addition.